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|Antigen||Growth Hormone Receptor (GHR) Antibodies|
|Epitope||AA 231-247, Middle Region Alternatives|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Growth Hormone Receptor antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-Growth Hormone Receptor AntibodyTarget Details Growth Hormone Receptor Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Growth hormone receptor(GHR) detection. Tested with WB in Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Growth hormone receptor(GHR) detection. Tested with WB in Mouse,Rat.
Gene Name: growth hormone receptor
Protein Name: Growth hormone receptor(GH receptor)
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor(231-247aa DKEHEVRVRSRQRSFEK), identical to the related rat sequence.|
Target Details Growth Hormone ReceptorProduct Details anti-Growth Hormone Receptor Antibody Application Details Handling Images back to top
|Alternative Name||GHR (GHR Antibody Abstract)|
The GHR locus to human chromosome 5p13.1-p12 and to mouse chromosome 15. Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb. GHR consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are 2 isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3(d3GHR). Furthermore, the two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing. In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the GHR gene have been demonstrated as the cause of Laron syndrome , also known as the growth hormone insensitivity syndrome(GHIS).
Synonyms: GH receptor antibody|GH-binding protein antibody|GHBP antibody|GHBP, included antibody|GHR antibody|GHR_HUMAN antibody|Growth hormone binding protein antibody|Growth hormone receptor antibody|Growth hormone receptor precursor antibody|Growth hormone-binding protein antibody|Growth hormone-binding protein, included antibody|Increased responsiveness to growth hormone, included antibody|Serum binding protein antibody|Serum-binding protein antibody|Somatotropin receptor antibody
|Pathways||NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus|
Application DetailsProduct Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Handling Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
ImagesProduct Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Application Details Handling back to top