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BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 (show NOTCH1 Proteins) intracellular domain, preventing the coactivator Mastermind-like1 (MAM1) from binding.
XMam1 has the ability to induce the cell fate into the neurogenic lineage in a Notch (show NOTCH1 Proteins)-independent manner
The present study shows a new role for Maml1 as a component of Shh (show SHH Proteins) signaling, which plays a crucial role in both development and tumorigenesis.
Similar phenotypes were observed by conditionally misexpressing a dominant negative form of MAML1 in Mitral cells ( MCs (show SMCP Proteins))after their migration. Furthermore, the intracellular domain of Notch1 (show NOTCH1 Proteins) (NICD1) was localized to nuclei of MCs (show SMCP Proteins). These findings suggest that Notch (show NOTCH1 Proteins) signaling at embryonic stages is involved in the dendritic complexity of MCs (show SMCP Proteins)
These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 (show RUNX2 Proteins) and plays a role in bone development.
This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine (show CCL1 Proteins) profiles and may also promote innate and adaptive immune cell infiltration and function.
Maml-mediated Notch (show NOTCH1 Proteins) signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis.
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Data demonstrate that Mesp2 (show Mesp2 Proteins) potently represses Notch (show NOTCH1 Proteins) signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway.
MAML1 is a novel modulator for NF-kappaB (show NFKB1 Proteins) signaling and regulates cellular survival.
There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis.
a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 (show NOTCH1 Proteins) inhibition
Authors report that p300 (show EP300 Proteins) and CBP (show CREBBP Proteins) acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 (show NOTCH1 Proteins) ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription.
MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma.
Notch (show NOTCH1 Proteins) signaling was altered in almost half of the clear-cell renal cell carcinoma (show MOK Proteins) patients and copy number variances in MAML1 and KAT2B (show KAT2B Proteins) were predominant changes.
The transcriptional coregulator MAML1 affects DNA methylation (show HELLS Proteins) and gene expression patterns in human embryonic kidney cells.
study identifies that MAML1 is ubiquitinated in the absence of Notch (show NOTCH1 Proteins) signaling to maintain low levels of MAML1 in the cell
In MCF-7 cells p53 (show TP53 Proteins) associates with the Notch (show NOTCH1 Proteins) transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53 (show TP53 Proteins)-MAML1 interaction.
The impact of MAML1 genetic variants to heart rate was discovered.
Data indicate that EpCAM (show EPCAM Proteins), CK19 (show KRT19 Proteins), and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients.
Snail (show SNAI1 Proteins) decreased transcription of Notch1 (show NOTCH1 Proteins) intracellular domain (NICD (show NOTCH1 Proteins)) target genes via competing with MAML1, co-activator, in NICD (show NOTCH1 Proteins) complex.
Authors report that human papillomavirus type 8 E6 subverts NOTCH (show NOTCH1 Proteins) activation during keratinocyte differentiation by inhibiting RBPJ (show RBPJ Proteins)/MAML1 transcriptional activator complexes at NOTCH (show NOTCH1 Proteins) target DNA.
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
, mastermind-like 1
, mastermind-like protein 1
, mastermind homolog