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NTAN1 Products

(N-terminal Asparagine Amidase (NTAN1))

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The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].

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Featured NTAN1 Categories

NTAN1 Antibodies

High quality antibodies with extensive validation data.

NTAN1 ELISA Kits

Reliable ELISA kits for a wide range of species.

NTAN1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NTAN1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7165837
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7246970
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN1536839
Quantity 400 μL
Datasheet Datasheet

Recommended NTAN1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN5595273
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6234098
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN6200673
Quantity 96 tests
Datasheet Datasheet

Recommended NTAN1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313099
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2727674
Quantity 20 μg
Datasheet Datasheet
Reactivity Pig
Source Yeast
Validations
Cat. No. ABIN1621088
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our NTAN1 products

Bahmani, Uehara, Ordikhani, Li, Jiang, Banouni, Ichimura, Kasinath, Eskandari, Annabi, Bromberg, Shultz, Greiner, Abdi: "Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery." in: EBioMedicine, Vol. 38, pp. 79-88, (2019) (PubMed).

Uehara, Li, Sheikhi, Zandi, Walker, Saleh, Banouni, Jiang, Ordikhani, Dai, Yonar, Vohra, Kasinath, Orgill, Khademhosseini, Annabi, Abdi: "Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival." in: Scientific reports, Vol. 9, Issue 1, pp. 6535, (2019) (PubMed).

Matsubara, Seki, Suzuki, Komori, Takamori: "Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors." in: Journal for immunotherapy of cancer, Vol. 7, Issue 1, pp. 256, (2019) (PubMed).

Bahmani, Uehara, Jiang, Ordikhani, Banouni, Ichimura, Solhjou, Furtmüller, Brandacher, Alvarez, von Andrian, Uchimura, Xu, Vohra, Yilmam, Haik, Azzi, Kasinath, Bromberg, McGrath, Abdi: "Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival." in: The Journal of clinical investigation, Vol. 128, Issue 11, pp. 4770-4786, (2018) (PubMed).

Jentho, Bodden, Schulz, Jung, Seidel, Schmeck, Bertrams: "microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1." in: PLoS ONE, Vol. 12, Issue 4, pp. e0176204, (2017) (PubMed).

Hautz, Zelger, Nasr, Mundinger, Barth, Rodriguez, Brandacher, Weissenbacher, Zelger, Cavadas, Margreiter, Lee, Pratschke, Lakkis, Schneeberger: "Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts." in: Transplant international : official journal of the European Society for Organ Transplantation, Vol. 27, Issue 9, pp. 966-76, (2014) (PubMed).

Hirakawa, Tsuboi, Sato, Kobayashi, Watanabe, Takakura, Imai, Ito, Fukuda, Kawashima: "Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing." in: The Journal of biological chemistry, Vol. 285, Issue 52, pp. 40864-78, (2010) (PubMed).

Burke, Dong, Hazan, Croy: "Aberrant endometrial features of pregnancy in diabetic NOD mice." in: Diabetes, Vol. 56, Issue 12, pp. 2919-26, (2007) (PubMed).

Drayton, Ying, Lee, Lesslauer, Ruddle: "Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase." in: The Journal of experimental medicine, Vol. 197, Issue 9, pp. 1153-63, (2003) (PubMed).

Samulowitz, Kuhn, Brachtendorf, Nawroth, Braun, Bankfalvi, Böcker, Vestweber: "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope." in: The American journal of pathology, Vol. 160, Issue 5, pp. 1669-81, (2002) (PubMed).

Synonyms and alternative names related to NTAN1

N-terminal Asn amidase (Ntan1), N-terminal asparagine amidase (NTAN1), PNAA, PNAD

Protein level used designations for NTAN1

  • N-terminal asparagine amidohydrolase
  • PNAA
  • PNAD
  • asparagine-specific N-terminal amidase
  • protein N-terminal Asn amidase
  • protein N-terminal asparagine amidohydrolase
  • protein NH2-terminal asparagine amidohydrolase
  • protein NH2-terminal asparagine deamidase
  • protein NTN-amidase
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