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MPP6 (show MPHOSPH6 Proteins) is a nucleolus-specific exosome co-factor required for its role in the maturation of 5.8S rRNA.
MPP6 (show MPHOSPH6 Proteins) was found to be associated with the exosome, a multiprotein complex involved in RNA degradation.
This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B (show EPB41L3 Proteins) in epithelial cells was not essential for the sorting of MPP6.
The findings indicate that the Src-MPP6-4.1G protein complex in Schmidt-Lanterman incisures(SLIs) has a role in signal transduction in the peripheral nervous system(PNS).
In the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI (show SHC2 Proteins)) and the paranodes with a member of the membrane-associated guanylate kinase (show GUK1 Proteins) (MAGUK) family, membrane protein palmitoylated (show MPP1 Proteins) 6.
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1\; MIM 601014), ZO1-like (see TJP1\; MIM 601009), p55-like (see MPP1\; MIM 305360), and LIN2-like (see CASK\; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001
MAGUK p55 subfamily member 6
, MAGUK protein p55T
, VELI-associated MAGUK 1
, protein associated with Lin7 2
, Fibroblast growth factor-inducible protein 15
, dlgh4 protein
, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 6)
, protein associated with Lin-7 2
, membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
, MAGUK p55 subfamily member 6-like protein
, membrane protein, palmitoylated 6 S homeolog