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Orthodenticle Homeobox 2 Products

(Orthodenticle Homeobox 2 (OTX2))
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012].

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Featured Orthodenticle Homeobox 2 Categories

Orthodenticle Homeobox 2 Antibodies

High quality antibodies with extensive validation data.

Orthodenticle Homeobox 2 ELISA Kits

Reliable ELISA kits for a wide range of species.

Orthodenticle Homeobox 2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Orthodenticle Homeobox 2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (1)
  • (6)
Cat. No. ABIN969332
Quantity 100 μL
Datasheet Datasheet

Application WB, IHC
Validations
  • (3)
  • (6)
Cat. No. ABIN2779643
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7074952
Quantity 100 μL
Datasheet Datasheet

Recommended Orthodenticle Homeobox 2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969088
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1137430
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1137429
Quantity 96 tests
Datasheet Datasheet

Recommended Orthodenticle Homeobox 2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124276
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3085429
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3121044
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Orthodenticle Homeobox 2 products

Karbalaie, Tanhaei, Rabiei, Kiani-Esfahani, Masoudi, Nasr-Esfahani, Baharvand: "Stem cells from human exfoliated deciduous tooth exhibit stromal-derived inducing activity and lead to generation of neural crest cells from human embryonic stem cells." in: Cell journal, Vol. 17, Issue 1, pp. 37-48, (2015) (PubMed).

Nagel, Ehrentraut, Meyer, Kaufmann, Drexler, MacLeod: "Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma." in: PLoS ONE, Vol. 10, Issue 9, pp. e0138416, (2015) (PubMed).

Machali?ska, Kawa, Pius-Sadowska, Rogi?ska, K?os, Baumert, Wiszniewska, Machali?ski: "Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair." in: Experimental eye research, Vol. 112, pp. 68-78, (2013) (PubMed).

Adamson, Shi, Wortham, Northcott, Di, Duncan, Li, McLendon, Bigner, Taylor, Yan: "OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas." in: Cancer research, Vol. 70, Issue 1, pp. 181-91, (2010) (PubMed).

Masuda, Esumi: "SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 26933-44, (2010) (PubMed).

Chung, Licznerski, Alavian, Simeone, Lin, Martin, Vance, Isacson: "The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons." in: Brain : a journal of neurology, Vol. 133, Issue Pt 7, pp. 2022-31, (2010) (PubMed).

Ashkenazi-Hoffnung, Lebenthal, Wyatt, Ragge, Dateki, Fukami, Ogata, Phillip, Gat-Yablonski: "A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency." in: Human genetics, Vol. 127, Issue 6, pp. 721-9, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Gonzalez-Rodriguez, Pelcastre, Tovilla-Canales, Garcia-Ortiz, Amato-Almanza, Villanueva-Mendoza, Espinosa-Mattar, Zenteno: "Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases." in: The British journal of ophthalmology, Vol. 94, Issue 8, pp. 1100-4, (2010) (PubMed).

Glubrecht, Kim, Russell, Bamforth, Godbout: "Differential CRX and OTX2 expression in human retina and retinoblastoma." in: Journal of neurochemistry, Vol. 111, Issue 1, pp. 250-63, (2009) (PubMed).

Synonyms and alternative names related to Orthodenticle Homeobox 2

orthodenticle homeobox 2 (OTX2), orthodenticle homeobox 2 (Otx2), orthodenticle homeobox 2 (otx2), orthodenticle homeobox 2 S homeolog (otx2.S), orthodenticle homeobox 2 L homeolog (otx2.L), CPHD6, E130306E05Rik, id:ibd2915, MCOPS5, otx-2, otx2, Xotx-2, Xotx2, zgc:136535, zotx-2, zOtx2

Protein level used designations for Orthodenticle Homeobox 2

  • homeobox protein OTX2
  • orthodenticle homolog 2
  • homeobox Otx2
  • etID309955.17
  • homeobox protein OTX2-A
  • orthodenticle 2-A
  • orthodenticle-A-like protein A
  • xOTX2-A
  • orthodenticle homeobox protein 2
  • homeobox protein OTX2-B
  • orthodenticle 2-B
  • orthodenticle-A-like protein B
  • xOTX2-B
  • LOW QUALITY PROTEIN: homeobox protein OTX2
  • orthodenticle 2
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