anti-Human CHEK2 antibody for ELISA

Recommended CHEK2 Antibody (supplied by: Log in to see )

Antigen
Checkpoint Kinase 2 (CHEK2) Antibodies
  • CDS1
  • CHK2
  • HuCds1
  • LFS2
  • PP1425
  • RAD53
  • hCds1
  • fa66f08
  • wu:fa66f08
  • zgc:55865
  • Cds1
  • HUCDS1
  • Rad53
  • Chk2
  • cds1
  • chek2
  • chk2
  • hucds1
  • lfs2
  • pp1425
  • rad53
  • checkpoint kinase 2
  • serine/threonine-protein kinase chk2
  • checkpoint kinase 2 L homeolog
  • CHEK2
  • chek2
  • Chek2
  • MCYG_07308
  • chek2.L
Epitope
AA 481-531
54
53
38
37
19
19
19
17
15
15
10
10
7
7
7
5
5
5
5
5
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
510
229
206
28
24
16
13
8
5
4
2
1
1
1
1
1
1
Host
Mouse
388
123
8
1
1
Clonality
Monoclonal
Conjugate
This CHEK2 antibody is un-conjugated
10
10
9
7
7
5
5
5
5
5
5
5
5
5
4
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
424
156
148
105
102
66
51
46
42
10
6
4
2
1
1
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Catalog No. ABIN1724714
$ 466.40
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
23.312359 ABIN393759 ELISA IF IHC WB Mouse IgG2a kappa AA 1-544 Log in to see 4B7 5
23.312359 ABIN564867 IF IHC (p) ELISA WB Mouse IgG2a kappa AA 1-543, full length Log in to see 4B7 0
21.778215 ABIN3181964 ELISA IHC WB Rabbit IgG pThr68 Log in to see Polyclonal 0
21.778215 ABIN932519 IF IHC ELISA WB Mouse IgG2b AA 481-531 Log in to see 1C12B8 0
20.278215 ABIN129576 ELISA WB Rabbit IgG AA 64-73, pThr68 Log in to see Polyclonal 1
19 ABIN6256592 ELISA ICC IF IHC WB Rabbit IgG pThr68 Log in to see Polyclonal 0
19 ABIN6256552 ELISA ICC IF IHC WB Rabbit IgG pThr383 Log in to see Polyclonal 0
19 ABIN6256554 ELISA ICC IF IHC WB Rabbit IgG pThr387 Log in to see Polyclonal 0
19 ABIN6271230 ELISA ICC IF IHC WB Rabbit IgG pSer28, pThr26 Log in to see Polyclonal 0
19 ABIN6255391 ELISA ICC IF IHC WB Rabbit IgG pSer516 Log in to see Polyclonal 0
18.778215 ABIN3183907 ELISA IHC WB Rabbit IgG Tyr60 Log in to see Polyclonal 0
17.278215 ABIN965887 IF IHC ELISA WB Mouse IgG2b AA 481-531 Log in to see 1C12B8 4
16 ABIN6271382 ELISA ICC IF IHC WB Rabbit IgG pSer33, pSer35 Log in to see Polyclonal 0
15.778215 ABIN3182510 ELISA IHC WB Rabbit IgG pThr387 Log in to see Polyclonal 0
15.778215 ABIN3181963 ELISA WB Rabbit IgG pSer516 Log in to see Polyclonal 0
15.778215 ABIN3182426 ELISA IF WB Rabbit IgG pThr383 Log in to see Polyclonal 0
15.778215 ABIN3183905 ELISA WB Rabbit IgG Tyr594, Tyr604 Log in to see Polyclonal 0
15.778215 ABIN3183906 ELISA IHC WB Rabbit IgG Tyr599 Log in to see Polyclonal 0
15.778215 ABIN3183904 ELISA IHC WB Rabbit IgG Tyr594 Log in to see Polyclonal 0
13 ABIN2869319 ELISA ICC IHC WB Mouse IgG2b AA 481-531 Log in to see 1C12B8 0

General

Antigen Checkpoint Kinase 2 (CHEK2) Antibodies
Epitope AA 481-531
(54), (53), (38), (37), (19), (19), (19), (17), (15), (15), (10), (10), (7), (7), (7), (5), (5), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(510), (229), (206), (28), (24), (16), (13), (8), (5), (4), (2), (1), (1), (1), (1), (1), (1)
Host Mouse
(388), (123), (8), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CHEK2 antibody is un-conjugated
(10), (10), (9), (7), (7), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(424), (156), (148), (105), (102), (66), (51), (46), (42), (10), (6), (4), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-CHEK2 Antibody

Target Details CHEK2 Application Details Handling References for anti-CHEK2 antibody (ABIN1724714) Images
Immunogen Purified recombinant fragment of human CHK2 (aa481-531) expressed in E. Coli.
Clone 1C12B8
Isotype IgG2b
Plasmids, Primers & others

Target Details CHEK2

Product Details anti-CHEK2 Antibody Application Details Handling References for anti-CHEK2 antibody (ABIN1724714) Images back to top
Antigen
Alternative Name CHK2 (CHEK2 Antibody Abstract)
Background CHK2: CHK2 checkpoint homolog (S. pombe). In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 61 kDa
Gene ID 11200
HGNC 11200
Pathways p53 Signaling, Apoptosis, Cell Division Cycle

Application Details

Product Details anti-CHEK2 Antibody Target Details CHEK2 Handling References for anti-CHEK2 antibody (ABIN1724714) Images back to top
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
Restrictions For Research Use only

Handling

Product Details anti-CHEK2 Antibody Target Details CHEK2 Application Details References for anti-CHEK2 antibody (ABIN1724714) Images back to top
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage

References for anti-CHEK2 antibody (ABIN1724714)

Product Details anti-CHEK2 Antibody Target Details CHEK2 Application Details Handling Images back to top
Product cited in:

Cybulski, Masojc, Oszutowska, Jaworowska, Grodzki, Waloszczyk, Serwatowski, Pankowski, Huzarski, Byrski, Górski, Jakubowska, Debniak, Wokolorczyk, Gronwald, Tarnowska, Serrano-Fernández, Lubinski et al.: "Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers. ..." in: Carcinogenesis, Vol. 29, Issue 4, pp. 762-5, 2008

Antoni, Sodha, Collins, Garrett: "CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?" in: Nature reviews. Cancer, Vol. 7, Issue 12, pp. 925-36, 2007

Bell, Kim, Godwin, Schiripo, Harris, Haserlat, Wahrer, Haiman, Daly, Niendorf, Smith, Sgroi, Garber, Olopade, Le Marchand, Henderson, Altshuler, Haber, Freedman: "Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts." in: International journal of cancer. Journal international du cancer, Vol. 121, Issue 12, pp. 2661-7, 2007

Images

Product Details anti-CHEK2 Antibody Target Details CHEK2 Application Details Handling References for anti-CHEK2 antibody (ABIN1724714) back to top
Supplier Images
Immunocytochemistry (ICC) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (ABIN1724714) anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody
Immunohistochemistry (IHC) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (ABIN1724714) anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (Image 2)
Western Blotting (WB) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (ABIN1724714) anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (Image 3)