anti-Mouse (Murine) RRM2B antibody for Immunohistochemistry

Recommended RRM2B Antibody (supplied by: Log in to see )

Antigen
Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) Antibodies
  • p53r2
  • RRM2B
  • MTDPS8A
  • MTDPS8B
  • P53R2
  • p53R2
  • ribonucleotide reductase M2 B (TP53 inducible) S homeolog
  • ribonucleotide reductase regulatory TP53 inducible subunit M2B
  • ribonucleotide reductase M2 B (TP53 inducible)
  • rrm2b.S
  • RRM2B
  • rrm2b
  • Rrm2b
Epitope
N-Term, pSer72
12
12
11
11
10
9
7
4
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
96
45
43
4
3
3
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
90
6
Clonality
Polyclonal
Conjugate
This RRM2B antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
78
42
17
15
13
10
4
3
2
1
1
1
Options
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Catalog No. ABIN966975
$ 559.35
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
17.752602 ABIN966974 IHC Rabbit N-Term Log in to see Polyclonal 5
10.12995 ABIN1031501 IHC ELISA WB Rabbit N-Term Log in to see Polyclonal 0
7.1299496 ABIN920915 IHC WB Rabbit Log in to see Polyclonal 0
1 ABIN1886848 IHC ELISA WB Rabbit AA 2-17 Log in to see Polyclonal 0
1 ABIN1737784 IHC WB Rabbit IgG AA 2-17 Log in to see Polyclonal 0
0.97972107 ABIN4343019 ELISA ICC IF IHC IHC (p) WB Rabbit N-Term Log in to see Polyclonal 0
-2.020279 ABIN4343021 IHC IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0

General

Antigen Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) Antibodies
Epitope N-Term, pSer72
(12), (12), (11), (11), (10), (9), (7), (4), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(96), (45), (43), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(90), (6)
Clonality
Polyclonal
Conjugate This RRM2B antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC)
(78), (42), (17), (15), (13), (10), (4), (3), (2), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-RRM2B Antibody

Target Details RRM2B Application Details Handling References for anti-RRM2B antibody (ABIN966975) Images
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human RRM2B (Ribonucleoside-diphosphate reductase subunit M2B)
Plasmids, Primers & others

Target Details RRM2B

Product Details anti-RRM2B Antibody Application Details Handling References for anti-RRM2B antibody (ABIN966975) Images back to top
Antigen
Alternative Name RRM2B (RRM2B Antibody Abstract)
Background RRM2B (Ribonucleoside-diphosphate reductase subunit M2B) plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. RRM2B supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. RRM2B contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. RRM2B binds 2 iron ions per subunit. RRM2B interacts with p53/TP53 and interacts with RRM1 in response to DNA damage. RRM2B is widely expressed at a high level in skeletal muscle and at a weak level in thymus. Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT)
Synonyms: P53R2( p53-inducible ribonucleotide reductase small subunit 2-like protein)
Pathways p53 Signaling, Negative Regulation of intrinsic apoptotic Signaling

Application Details

Product Details anti-RRM2B Antibody Target Details RRM2B Handling References for anti-RRM2B antibody (ABIN966975) Images back to top
Restrictions For Research Use only

References for anti-RRM2B antibody (ABIN966975)

Product Details anti-RRM2B Antibody Target Details RRM2B Application Details Handling Images back to top
Background publications

Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: "The full-ORF clone resource of the German cDNA Consortium." in: BMC genomics, Vol. 8, pp. 399, 2008

Tanaka, Arakawa, Yamaguchi, Shiraishi, Fukuda, Matsui, Takei, Nakamura: "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage." in: Nature, Vol. 404, Issue 6773, pp. 42-9, 2000

Product cited in:

Xue, Zhou, Liu, Qiu, Jin, Yen: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." in: Cancer research, Vol. 63, Issue 5, pp. 980-6, 2003

Guittet, Håkansson, Voevodskaya, Fridd, Gräslund, Arakawa, Nakamura, Thelander: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, 2001

Yamaguchi, Matsuda, Sagiya, Iwadate, Fujino, Nakamura, Arakawa: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." in: Cancer research, Vol. 61, Issue 22, pp. 8256-62, 2001