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General |
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Antigen | Twist Homolog 1 (Drosophila) (TWIST1) Antibodies |
Epitope | C-Term Alternatives |
Reactivity | Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This TWIST1 antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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2 references available |
Supplier | Log in to see |
Product Details anti-TWIST1 AntibodyTarget Details TWIST1 Application Details Handling References for anti-TWIST1 antibody (ABIN2780347) Images |
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Sequence | DKLSKIQTLK LAARYIDFLY QVLQSDELDS KMASCSYVAH ERLSYAFSVW |
Predicted Reactivity | Cow: 100%, Dog: 79%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 79%, Rat: 100%, Zebrafish: 100% |
Characteristics | This is a rabbit polyclonal antibody against TWIST1. It was validated on Western Blot using a cell lysate as a positive control. |
Purification | Protein A purified |
Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human TWIST1 |
Plasmids, Primers & others | |
Target Details TWIST1Product Details anti-TWIST1 Antibody Application Details Handling References for anti-TWIST1 antibody (ABIN2780347) Images back to top |
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Antigen | |
Alternative Name | TWIST1 (TWIST1 Antibody Abstract) |
Background |
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation.TWIST1 is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue, in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. Alias Symbols: SCS, ACS3, CRS1, BPES2, BPES3, TWIST, bHLHa38 Protein Interaction Partner: UBC, HOXA5, ETS2, TP53, KAT2B, SETD8, HES6, MTA2, BRAP, TCF3, RELA, PPP2CA, HDAC2, CHD3, TWIST2, ELSPBP1, WDR5, HDAC3, RBBP7, CHD4, SOX2, EP300, TWIST1, GLI3, MYOD1, Protein Size: 202 |
Molecular Weight | 21 kDa |
Gene ID | 7291 |
NCBI Accession | NM_000474, NP_000465 |
UniProt | Q15672 |
Pathways | p53 Signaling, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity |
Application DetailsProduct Details anti-TWIST1 Antibody Target Details TWIST1 Handling References for anti-TWIST1 antibody (ABIN2780347) Images back to top |
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Application Notes | Optimal working dilutions should be determined experimentally by the investigator. |
Comment |
Antigen size: 202 AA |
Restrictions | For Research Use only |
HandlingProduct Details anti-TWIST1 Antibody Target Details TWIST1 Application Details References for anti-TWIST1 antibody (ABIN2780347) Images back to top |
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Format | Liquid |
Concentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
References for anti-TWIST1 antibody (ABIN2780347)Product Details anti-TWIST1 Antibody Target Details TWIST1 Application Details Handling Images back to top |
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Product cited in: |
Guha, Bandyopadhyaya, Polumuri, Chumsri, Gade, Kalvakolanu, Ahmed et al.: "Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic ..." in: Breast cancer research and treatment, Vol. 145, Issue 1, pp. 5-22, 2014 |
Background publications |
Reinhold, Kapadia, Liao, Naski: "The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis." in: The Journal of biological chemistry, Vol. 281, Issue 3, pp. 1381-8, 2006 |
ImagesProduct Details anti-TWIST1 Antibody Target Details TWIST1 Application Details Handling References for anti-TWIST1 antibody (ABIN2780347) back to top |
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Supplier Images |