CD80 Detection Set (Risk Free)
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- Target See all CD80 products
- CD80
- Binding Specificity
- Extracellular Domain
- Reactivity
- Human
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Host
- Mouse
- Clonality
- Monoclonal
- Application
- ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Brand
- Risk-Free™
- Characteristics
- CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).
- Purification
- Antibodies are supplied as protein A purified IgG1 and IgG2b.
- Components
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CD80 Antibody [8G12]
CD80 Antibody [10A1]
CD80 Antibody [7A2]
CD80 Antibody [11D1]
CD80 Antibody [11C12]
CD80 Antibody [12D9] - Immunogen
- CD80 antibodies were raised against the extracellular domain of human CD80.
- Isotype
- IgG1, IgG2b
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CD80 (Human) Matched Antibody Pair
ELISA Reactivity: Human ELISA unconjugated Host: Mouse
CD80 (Human) IP-WB Antibody PairIP Reactivity: Human IP unconjugated Host: Rabbit, Mouse
CD80 (Human) IP-WB Antibody PairIP Reactivity: Human IP unconjugated Host: Rabbit, Mouse
CD80 (Human) IP-WB Antibody PairIP Reactivity: Human IP unconjugated Host: Rabbit, Mouse
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- Comment
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Risk-Free™ antibodies are monoclonal antibodies made to improve in vitro studies.
Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein.
These antibodies have the following advantages:
- Antibodies are developed against mammalian-expressed, post-translationally modified recombinant proteins.
- Multiple antibodies per target allows the user to choose the best antibody for their application
- Available individually or as a set
- Risk-Free™ means they are rigorously tested and guaranteed to work for their designated applications:
- ELISA
- Flow Cytometry
- Immunoblot
- Immunohistochemistry
- Immunocytochemistry
- Immunofluorescence - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Target
- CD80
- Alternative Name
- CD80 (CD80 Products)
- Synonyms
- B7 Matched Antibody Pair, B7-1 Matched Antibody Pair, B7.1 Matched Antibody Pair, BB1 Matched Antibody Pair, CD28LG Matched Antibody Pair, CD28LG1 Matched Antibody Pair, LAB7 Matched Antibody Pair, B71 Matched Antibody Pair, Cd28l Matched Antibody Pair, Ly-53 Matched Antibody Pair, Ly53 Matched Antibody Pair, MIC17 Matched Antibody Pair, TSA1 Matched Antibody Pair, CD80 molecule Matched Antibody Pair, Cd80 molecule Matched Antibody Pair, CD80 antigen Matched Antibody Pair, CD80 Matched Antibody Pair, Cd80 Matched Antibody Pair
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