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cathepsin Z has a critical role during nematode development
we evaluated the involvement of cathepsin B (show CTSB Antibodies) and X in the TGF-b1 signaling pathway, one of the key signaling mechanisms triggering epithelial-mesenchymal transition in cancer. In MCF-7 cells the expression of cathepsin B (show CTSB Antibodies) was shown to depend on their activation with TGF-b1 while, for cathepsin X (show CTSK Antibodies), a TGF-b1 independent mechanism of induction during EMT (show ITK Antibodies) is indicated.
Down-regulation of RPLP0 (show RPLP0 Antibodies) resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X (show CTSK Antibodies) led to G1 arrest and apoptosis
Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer.
The significant association of cathepsin X (show CTSK Antibodies) with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy.
Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population.
We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1 (show ITGAL Antibodies), by CatX, enhances binding of the adaptor protein talin to LFA-1 (show ITGAL Antibodies) and triggers formation of the latter's high-affinity form
cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
cathepsin X (show CTSK Antibodies) deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X (show CTSK Antibodies) in bypassing cellular senescence.
Polymorphisms in MC3R (show MC3R Antibodies) promoter and CTSZ 3'UTR (show UTS2R Antibodies) are associated with tuberculosis susceptibility.
Cysteine proteases bleomycin hydrolase (show BLMH Antibodies) and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin (show HTT Antibodies).
CTSZ associates with growth and with meat colour, with the less favourable genotype for growth being associated with darker meat.
The data support a novel role for cathepsin Z in the propagation of IL-1beta (show IL1B Antibodies)-driven neuroinflammation.
nigericin-induced cell death depended partly on a single cathepsin, cathepsin X.
tumor proliferation was exclusively regulated by cancer cell-intrinsic functions of CtsZ, whereas tumor invasion required contributions from both macrophages and cancer cell
Our data show an active role for Ctsz in chronic inflammation and the development of gastric metaplasia.
Plaque-associated microglial cells express gamma-enolase (show ENO2 Antibodies) and cathepsin X.
analysis of cathepsin X-deficient gastric epithelial cells in co-culture with macrophages during Helicobacter pylori infection
Data show that combined loss of Ctsb (show CTSB Antibodies) and Ctsz led to additive effects, resulting in significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading and 70% reduction in the number of lung metastases.
regulation of the phagosomal CatZ, CatB, CatL and CatS contents during dendritic cell activation
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.
CathePsin Z family member (cpz-1)
, CathePsin Z family member (cpz-2)
, cathepsin Z
, cathepsin z
, carboxypeptidase LB
, cathepsin B2
, cathepsin IV
, cathepsin P
, cathepsin X
, cathepsin Y
, cathepsin Z1
, cysteine-type carboxypeptidase
, lysosomal carboxypeptidase B
, preprocathepsin P