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anti-Human Cathepsin Z Antibodies:
anti-Mouse (Murine) Cathepsin Z Antibodies:
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cathepsin Z has a critical role during nematode development
expression of cathepsin B and X was detected in stromal cells and cancer cells throughout the glioblastoma (GBM) sections, whereas cathepsin K expression was more restricted to arteriole-rich regions in the GBM sections. Metabolic mapping showed that cathepsin B, but not cathepsin K is active in GSC niches.
we evaluated the involvement of cathepsin B and X in the TGF-b1 signaling pathway, one of the key signaling mechanisms triggering epithelial-mesenchymal transition in cancer. In MCF-7 cells the expression of cathepsin B was shown to depend on their activation with TGF-b1 while, for cathepsin X, a TGF-b1 independent mechanism of induction during EMT is indicated.
Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis
Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer.
The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy.
Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population.
We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form
Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence.
Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.
associated with tuberculosis in a Ugandan household contact study
Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.
These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity.
the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components [Cathepsin X]
unlikely that CTSZ gene plays a major role in tuberculosis susceptibility in African populations
CTSZ associates with growth and with meat colour, with the less favourable genotype for growth being associated with darker meat.
The data support a novel role for cathepsin Z in the propagation of IL-1beta-driven neuroinflammation.
nigericin-induced cell death depended partly on a single cathepsin, cathepsin X.
tumor proliferation was exclusively regulated by cancer cell-intrinsic functions of CtsZ, whereas tumor invasion required contributions from both macrophages and cancer cell
Our data show an active role for Ctsz in chronic inflammation and the development of gastric metaplasia.
Plaque-associated microglial cells express gamma-enolase and cathepsin X.
analysis of cathepsin X-deficient gastric epithelial cells in co-culture with macrophages during Helicobacter pylori infection
Data show that combined loss of Ctsb and Ctsz led to additive effects, resulting in significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading and 70% reduction in the number of lung metastases.
regulation of the phagosomal CatZ, CatB, CatL and CatS contents during dendritic cell activation
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.
CathePsin Z family member (cpz-1)
, CathePsin Z family member (cpz-2)
, cathepsin Z
, cathepsin z
, carboxypeptidase LB
, cathepsin B2
, cathepsin IV
, cathepsin P
, cathepsin X
, cathepsin Y
, cathepsin Z1
, cysteine-type carboxypeptidase
, lysosomal carboxypeptidase B
, preprocathepsin P