Sphingomyelin Synthase 1 (SGMS1) (Middle Region) Peptide
SGMS1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all Sphingomyelin Synthase 1 (SGMS1) products
- Sphingomyelin Synthase 1 (SGMS1)
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LTTVMISVVH ERVPPKEVQP PLPDTFFDHF NRVQWAFSIC EINGMILVGL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Sgms1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Sphingomyelin Synthase 1 (SGMS1)
- Synonyms
- MGC81436 Peptide, TMEM23 Peptide, MOB Peptide, MOB1 Peptide, SMS1 Peptide, hmob33 Peptide, 9530058O11Rik Peptide, AI841905 Peptide, C80702 Peptide, Mob Peptide, Sms1 Peptide, Sor1 Peptide, Tmem23 Peptide, sphingomyelin synthase 1 Peptide, sphingomyelin synthase 1 S homeolog Peptide, phosphatidylcholine:ceramide cholinephosphotransferase 1 Peptide, SGMS1 Peptide, sgms1.S Peptide, LOC100013212 Peptide, Sgms1 Peptide
- Background
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Bidirectional lipid cholinephosphotransferase is capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Sgms1 directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Sgms1 does not function strictly as a SM synthase and suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sgms1 may protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
Alias Symbols: 9530058O11Rik, AI841905, C80702, MGC30540, Mob, Sms1, Sor1, Tmem23
Protein Size: 419 - Molecular Weight
- 46 kDa
- Gene ID
- 208449
- NCBI Accession
- NM_144792, NP_659041
- UniProt
- Q8VCQ6
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