V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb) (Middle Region) Peptide
Ralb
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all RALB (Ralb) products
- RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EHESFTATAE FREQILRVKS EEDKIPLLVV GNKSDLEERR QVPVDEARGK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Ralb Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RALB (Ralb) (V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) (Ralb))
- Synonyms
- dRalb Peptide, 5730472O18Rik Peptide, Ral B Peptide, ralb Peptide, xralb Peptide, zgc:100801 Peptide, KRAS2 Peptide, k-ras Peptide, RAS like proto-oncogene B Peptide, v-ral simian leukemia viral oncogene B Peptide, v-ral simian leukemia viral oncogene homolog B L homeolog Peptide, v-ral simian leukemia viral oncogene homolog Ba (ras related) Peptide, v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) Peptide, RALB Peptide, Ralb Peptide, ralb.L Peptide, ralba Peptide, ralb Peptide
- Background
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Ralb is a multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Ralb accomplishes its multiple functions by interacting with distinct downstream effectors. It acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. It is required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Ralb plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. It is required for suppression of apoptosis.
Alias Symbols: 5730472O18Rik
Protein Size: 206 - Molecular Weight
- 23 kDa
- Gene ID
- 64143
- NCBI Accession
- NM_022327, NP_071722
- UniProt
- Q9JIW9
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