Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N) (N-Term) Peptide
PCSK1N
Reactivity: Human, Rat
Host: Synthetic
BP, WB
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- Target See all PCSK1N products
- PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))
- Protein Region
- N-Term
- Origin
- Human, Rat
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- STPLRLRRAV PRGEAAGAVQ ELARALAHLL EAERQERARA EAQEAEDQQA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Pcsk1n Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))
- Synonyms
- PROSAAS Peptide, SAAS Peptide, Saas Peptide, AI848336 Peptide, KEP Peptide, PEN Peptide, PEN19 Peptide, PEN20 Peptide, Pan3 Peptide, SAASCT Peptide, bLEN Peptide, lLEN Peptide, proSAAS Peptide, proprotein convertase subtilisin/kexin type 1 inhibitor Peptide, PCSK1N Peptide, Pcsk1n Peptide
- Background
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Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Alias Symbols: Saas
Protein Size: 260 - Molecular Weight
- 28 kDa
- Gene ID
- 246333
- NCBI Accession
- NM_019279, NP_062152
- UniProt
- Q9QXU9
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