Chromosome 1 Open Reading Frame 124 (C1orf124) (Middle Region) Peptide
C1orf124
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Spartan (C1orf124) products
- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ATNREPSAHD YWWAEHQKTC GGTYIKIKEP ENYSKKGKGK AKLGKEPVLA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SPRTN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))
- Synonyms
- Spartan Peptide, c1orf124 Peptide, C1orf124 Peptide, DDDL1880 Peptide, DVC1 Peptide, PRO4323 Peptide, dJ876B10.3 Peptide, C28H1orf124 Peptide, SprT-like N-terminal domain Peptide, sprtn Peptide, SPRTN Peptide
- Background
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SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
Alias Symbols: C1orf124, DDDL1880, PRO4323, Spartan, dJ876B10.3
Protein Size: 489 - Molecular Weight
- 55 kDa
- Gene ID
- 83932
- NCBI Accession
- NM_032018, NP_114407
- UniProt
- Q9H040
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