DNA-Damage-Inducible Transcript 3 (DDIT3) (N-Term) Peptide
DDIT3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all DDIT3 products
- DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SLPFSFGTLS SWELEAWYED LQEVLSSDEN GGTYVSPPGN EEEESKIFTT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-DDIT3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))
- Synonyms
- chop Peptide, Xchop Peptide, cebpz Peptide, chop10 Peptide, gadd153 Peptide, CHOP-10 Peptide, CHOP10 Peptide, CHOP Peptide, Chop10 Peptide, Gadd153 Peptide, CEBPZ Peptide, GADD153 Peptide, DNA damage inducible transcript 3 Peptide, DNA-damage inducible transcript 3 Peptide, DNA damage inducible transcript 3 L homeolog Peptide, ddit3 Peptide, Ddit3 Peptide, DDIT3 Peptide, ddit3.L Peptide
- Background
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This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
Protein Size: 192 - Molecular Weight
- 21 kDa
- Gene ID
- 1649
- NCBI Accession
- NP_001181985
- UniProt
- F8VS99
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