Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) (Middle Region) Peptide
KCNJ11
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all KCNJ11 products
- KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))
- Protein Region
- Middle Region
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SMIISATIHM QVVRKTTSPE GEVVPLHQVD IPMENGVGGN SIFLVAPLII
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-KCNJ11 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))
- Synonyms
- kir6.2 Peptide, Kir6.2 Peptide, mBIR Peptide, BIR Peptide, HHF2 Peptide, IKATP Peptide, KIR6.2 Peptide, PHHI Peptide, TNDM3 Peptide, potassium voltage-gated channel subfamily J member 11 Peptide, potassium inwardly-rectifying channel, subfamily J, member 11 Peptide, potassium inwardly rectifying channel, subfamily J, member 11 Peptide, KCNJ11 Peptide, kcnj11 Peptide, Kcnj11 Peptide
- Background
-
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM).
Alias Symbols: BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Protein Size: 303 - Molecular Weight
- 33 kDa
- Gene ID
- 3767
- NCBI Accession
- NM_001166290, NP_001159762
-
You are here:
