Major Histocompatibility Complex, Class II, DO beta (HLA-DOB) (N-Term) Peptide
HLA-DOB
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HLA-DOB products
- HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LTRLDSSMTQ GTDSPEDFVI QAKADCYFTN GTEKVQFVVR FIFNLEEYVR
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HLA-DOB Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
- Synonyms
- DOB Peptide, major histocompatibility complex, class II, DO beta Peptide, HLA-DOB Peptide, PATR-DOB Peptide
- Background
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HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Alias Symbols: DOB
Protein Size: 273 - Molecular Weight
- 30 kDa
- Gene ID
- 3112
- NCBI Accession
- NM_002120, NP_002111
- UniProt
- Q5QNS2
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