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HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) (N-Term) Peptide

HACE1 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN2183577
  • Target See all HACE1 products
    HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    RARTVELPED NETAVYTLMP MVMADQHRSV SELLSNSKFD VNYAFGRVKR
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-HACE1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
    Synonyms
    HACE1 Peptide, 1700042J16Rik Peptide, A730034A22Rik Peptide, BC025474 Peptide, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Peptide, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog Peptide, HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 Peptide, HACE1 Peptide, hace1 Peptide, hace1.L Peptide, Hace1 Peptide
    Background
    HACE1 is a E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. It acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. It acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. HACE1 specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. It may also act as a transcription regulator via its interaction with RARB.

    Alias Symbols: -

    Protein Size: 694
    Molecular Weight
    76 kDa
    Gene ID
    57531
    NCBI Accession
    NM_020771, NP_065822
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