Heparin-Binding EGF-Like Growth Factor (HBEGF) (N-Term) Peptide
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- Target See all HBEGF products
- HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- FLAAVLSALV TGESLERLRR GLAAGTSNPD PPTVSTDQLL PLGGGRDRKV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HBEGF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
- Synonyms
- hbegf Peptide, zgc:165443 Peptide, HBEGF Peptide, zgc:175091 Peptide, DTR Peptide, DTS Peptide, DTSF Peptide, HEGFL Peptide, Dtr Peptide, GFHB Peptide, Hb-egf Peptide, Hegfl Peptide, AW047313 Peptide, Dts Peptide, HB-EGF Peptide, heparin-binding EGF-like growth factor b Peptide, heparin binding EGF like growth factor Peptide, Heparin-binding EGF-like growth factor Peptide, heparin-binding EGF-like growth factor a Peptide, heparin-binding EGF-like growth factor Peptide, hbegfb Peptide, HBEGF Peptide, hbegf Peptide, hbegfa Peptide, Hbegf Peptide
- Background
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HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
Alias Symbols: DTR, DTS, DTSF, HEGFL
Protein Size: 208 - Molecular Weight
- 22 kDa
- Gene ID
- 1839
- NCBI Accession
- NM_001945, NP_001936
- UniProt
- Q99075
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