Glial Cells Missing Homolog 2 (GCM2) (N-Term) Peptide
GCM2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GCM2 products
- GCM2 (Glial Cells Missing Homolog 2 (GCM2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- HSGYPVTNFW RLDGNAIFFQ AKGVHDHPRP ESKSETEARR SAIKRQMASF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GCM2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GCM2 (Glial Cells Missing Homolog 2 (GCM2))
- Synonyms
- GCMb Peptide, Gcm-2 Peptide, gcm-2 Peptide, GCMB Peptide, hGCMb Peptide, Gcm-rs1 Peptide, Gcm1 Peptide, Gcm1-rs2 Peptide, glial cells missing homolog 2 Peptide, glial cells missing homolog 2 (Drosophila) Peptide, glial cells missing homolog 2 S homeolog Peptide, GCM2 Peptide, gcm2 Peptide, gcm2.S Peptide, Gcm2 Peptide
- Background
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This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.
Alias Symbols: GCMB, hGCMb
Protein Size: 506 - Molecular Weight
- 57 kDa
- Gene ID
- 9247
- NCBI Accession
- NM_004752, NP_004743
- UniProt
- O75603
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