Retinoblastoma 1 (RB1) (Middle Region) Peptide
RB1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all Retinoblastoma 1 (RB1) products
- Retinoblastoma 1 (RB1)
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TETQAASAFH TQKPLKSTSL ALFYKKVYRL AYLRLNTLCA RLLSDHPELE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Rb1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Retinoblastoma 1 (RB1)
- Synonyms
- OSRC Peptide, RB Peptide, p105-Rb Peptide, pRb Peptide, pp110 Peptide, Rb Peptide, Rb-1 Peptide, P105-RB Peptide, PP110 Peptide, RB11 Peptide, zgc:154147 Peptide, RB transcriptional corepressor 1 Peptide, RB transcriptional corepressor like 1 Peptide, retinoblastoma 1 Peptide, RB1 Peptide, RBL1 Peptide, Rb1 Peptide, rb1 Peptide
- Background
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SLC11A1 is key regulator of entry into cell division that acts as a tumor suppressor. It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. It mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex By similarity.
Alias Symbols: Rb, Rb-1, pRb
Protein Size: 921 - Molecular Weight
- 101 kDa
- Gene ID
- 19645
- NCBI Accession
- NM_009029, NP_033055
- UniProt
- P13405
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