EPH Receptor A6 (Epha6) Peptide
Epha6
Reactivity: Human, Mouse, Rat
Host: Synthetic
BP, WB, ICo, IDe
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- Target See all EPH Receptor A6 (Epha6) products
- EPH Receptor A6 (Epha6)
- Peptide Type
- Synthetic
- Origin
- Human, Mouse, Rat
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunocompetition (ICo), Immunodepletion (IDe)
- Purification
- Synthetic Peptide
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Storage
- -20 °C
- Storage Comment
- For long-term storage of keep at -20 °C.
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- Target
- EPH Receptor A6 (Epha6)
- Synonyms
- EPHA6 Peptide, Ehk2 Peptide, Hek12 Peptide, m-ehk2 Peptide, EHK-2 Peptide, EHK2 Peptide, EK12 Peptide, EPA6 Peptide, HEK12 Peptide, PRO57066 Peptide, EPH receptor A6 Peptide, Eph receptor A6 Peptide, EPHA6 Peptide, epha6 Peptide, Epha6 Peptide
- Background
- Ephrin A6, a member of the ephrin family, elicits biological responses in retinal neurons. It binds with high affinity to several other EphA receptors and causes growth cone collapse in retinal explants. Ephrin-A6 expression is high at embryonic day 6 (E6) and at embryonic day 8 (E8), when retinal axons grow to their tectal targets, and then this Ephrin-A6 expression gradually declines at later developmental stages. This new ephrin plays a role in the establishment of visual system topography as observed by the asymmetric distribution of ephrin-A6 in retinal cells. High levels of expression of Eph-A6 in the macula of developing human retina showed localization of Eph-A6 to (GC) ganglion cells. Eph receptors and Ephrins have indeed been implicated in multiple aspects of synaptic function, including clustering and modulating N-methyl-D-aspartate receptors, modifying the geometry of postsynaptic terminals, and influencing long-term synaptic plasticity and memory. Eph A6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits of learning and memory. Genetic inhibition of the ephrin receptor (Eph A6) in knockout mice produced behavioral deficits in tests of learning and memory. The gene for EphAR6 is present on chromosome 3q11.2
- NCBI Accession
- NP_001073917
- UniProt
- B3KS12
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