Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1) Peptide
ROBO1
Reactivity: Human
Host: Rabbit
BP
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- Target See all ROBO1 products
- ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
- Origin
- Human
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Source
- Rabbit
- Application
- Blocking Peptide (BP)
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- Restrictions
- For Research Use only
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- Storage
- -20 °C
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- Target
- ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
- Synonyms
- DUTT1 Peptide, SAX3 Peptide, AW494633 Peptide, AW742721 Peptide, Gm310 Peptide, ROBO1 Peptide, dutt1 Peptide, roundabout Peptide, sax3 Peptide, MGC122264 Peptide, roundabout-1 Peptide, roundabout guidance receptor 1 Peptide, roundabout, axon guidance receptor, homolog 1 (Drosophila) Peptide, roundabout guidance receptor 1 L homeolog Peptide, ROBO1 Peptide, Robo1 Peptide, robo1 Peptide, robo1.L Peptide
- Background
- Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.
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