Adenylate Cyclase Activating Polypeptide 1 (Pituitary) (ADCYAP1) (AA 6-38) Peptide
ADCYAP1
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- Target See all PACAP (ADCYAP1) products
- PACAP (ADCYAP1) (Adenylate Cyclase Activating Polypeptide 1 (Pituitary) (ADCYAP1))
- Protein Region
- AA 6-38
- Purification
- Purified
- Purity
- > 95 %
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Adenylate Cyclase Activating Polypeptide 1 (Pituitary) (ADCYAP1) peptide
ADCYAP1 Reactivity: Mouse Host: Escherichia coli (E. coli) ELISA, IP, SDS, WB Dithiothreitol (DTT)
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- Restrictions
- For Research Use only
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- Storage
- -20 °C
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- Target
- PACAP (ADCYAP1) (Adenylate Cyclase Activating Polypeptide 1 (Pituitary) (ADCYAP1))
- Synonyms
- PACAP Peptide, grf Peptide, Pacap Peptide, adcyap1 Peptide, GRF-PACAP Peptide, zgc:103760 Peptide, xx:af217251 Peptide, pacap Peptide, ADCYAP1 Peptide, PACAP2 Peptide, acap1l Peptide, pacap1b Peptide, wu:fj30e08 Peptide, zgc:101522 Peptide, zgc:92555 Peptide, adenylate cyclase activating polypeptide 1 Peptide, adenylate cyclase activating polypeptide 1a Peptide, adenylate cyclase activating polypeptide 1 (pituitary) Peptide, adenylate cyclase activating polypeptide 1b Peptide, ADCYAP1 Peptide, Adcyap1 Peptide, adcyap1a Peptide, adcyap1 Peptide, adcyap1b Peptide
- Background
- PACAP (6-38) is a potent antagonist of PACAP 38. PACAP (6-38) is much more potent and selective than PACAP (6-27) in the inhibition of PACAP-27-stimulated pituitary adenylate cyclase. Ki values for the inhibition of the enzyme were 7nM and 150 nM, respectively. PACAP (6-38) caused a small but significant (approximately 20%) inhibition of the NANC relaxation due to electrical field stimulation (1 Hz or 10 Hz for 20 s). At these frequencies PACAP (6-38) caused no inhibition of the NANC relaxation in the presence of the P2 purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (or PPADS) plus the NO-synthase blocker NG-nitro-L-arginine, in preparations pretreated with L-NOARG alone, PACAP (6-38) retained its inhibitory effect.
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