Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (Middle Region) Peptide
TNFSF11
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all RANKL (TNFSF11) products
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PFAHLTINAT DIPSGSHKVS LSSWYHDRGW AKISNMTFSN GKLIVNQDGF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- TNFSF11 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
- Synonyms
- CD254 Peptide, ODF Peptide, OPGL Peptide, OPTB2 Peptide, RANKL Peptide, TRANCE Peptide, hRANKL2 Peptide, sOdf Peptide, TNFSF11 Peptide, Ly109l Peptide, OPG Peptide, Trance Peptide, cd254 Peptide, odf Peptide, opgl Peptide, optb2 Peptide, rankl Peptide, sodf Peptide, tnfsf11 Peptide, trance Peptide, TNF superfamily member 11 Peptide, tumor necrosis factor (ligand) superfamily, member 11 Peptide, TNF receptor superfamily member 11b Peptide, TNF superfamily member 11 L homeolog Peptide, TNFSF11 Peptide, Tnfsf11 Peptide, TNFRSF11B Peptide, tnfsf11.L Peptide
- Background
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This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Alias Symbols: ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2
Protein Size: 317 - Gene ID
- 8600
- NCBI Accession
- NM_003701, NP_003692
- UniProt
- O14788
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