Fibroblast Growth Factor Receptor 3 (FGFR3) (C-Term) Peptide
FGFR3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FGFR3 products
- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KQLVEDLDRV LTVTSTDEYL DLSAPFEQYS PGGQDTPSSS SSGDDSVFAH
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- FGFR3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
- Synonyms
- FGFR3 Peptide, LOC100034114 Peptide, ACH Peptide, CD333 Peptide, CEK2 Peptide, HSFGFR3EX Peptide, JTK4 Peptide, FR3 Peptide, Fgfr-3 Peptide, Flg-2 Peptide, HBGFR Peptide, Mfr3 Peptide, sam3 Peptide, fc27h01 Peptide, wu:fc27h01 Peptide, fibroblast growth factor receptor 3 Peptide, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog Peptide, FGFR3 Peptide, fgfr3.S Peptide, Fgfr3 Peptide, fgfr3 Peptide
- Background
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This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Alias Symbols: ACH, CEK2, JTK4, CD333, HSFGFR3EX
Protein Size: 480 - Gene ID
- 2261
- NCBI Accession
- NM_000142, NP_000133
- UniProt
- Q0IJ44
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