Desmocollin 3 (DSC3) (Middle Region) Peptide
DSC3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Desmocollin 3 (DSC3) products
- Desmocollin 3 (DSC3)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- IKENLAVGSK INGYKAYDPE NRNGNGLRYK KLHDPKGWIT IDEISGSIIT
- Characteristics
- This is a synthetic peptide designed for use in combination with DSC3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Desmocollin 3 (DSC3)
- Synonyms
- CDHF3 Peptide, DSC Peptide, DSC1 Peptide, DSC2 Peptide, DSC4 Peptide, HT-CP Peptide, 5430426I24Rik Peptide, MGC85083 Peptide, desmocollin 3 Peptide, desmocollin 3 S homeolog Peptide, DSC3 Peptide, Dsc3 Peptide, dsc3.S Peptide, dsc3 Peptide
- Background
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The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.
Alias Symbols: DSC, DSC1, DSC2, DSC4, CDHF3, HT-CP
Protein Size: 839 - Gene ID
- 1825
- NCBI Accession
- NM_001941, NP_001932
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