Maternal Embryonic Leucine Zipper Kinase (MELK) (Middle Region) Peptide
MELK
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MELK products
- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MEETPKRKGA KVFGSLERGL DKVITVLTRS KRKGSARDGP RRLKLHYNVT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MELK Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Maternal Embryonic Leucine Zipper Kinase (MELK) peptide
MELK Reactivity: Human, Mouse, Cow, Dog Host: Synthetic BP, Imm
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
- Synonyms
- MELK Peptide, xmelk Peptide, Melk Peptide, HPK38 Peptide, AI327312 Peptide, MPK38 Peptide, mKIAA0175 Peptide, fb71b01 Peptide, fe01f04 Peptide, wu:fb71b01 Peptide, wu:fe01f04 Peptide, maternal embryonic leucine zipper kinase Peptide, maternal embryonic leucine zipper kinase L homeolog Peptide, MELK Peptide, melk Peptide, cgd5_2270 Peptide, Melk Peptide, melk.L Peptide
- Background
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MELK is a serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. It acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. And it plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. It may also play a role in primitive hematopoiesis.
Alias Symbols: MELK,KIAA0175,
Protein Size: 457 - Gene ID
- 9833
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