Centrosomal Protein 57kDa (CEP57) (Middle Region) Peptide
CEP57
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CEP57 products
- CEP57 (Centrosomal Protein 57kDa (CEP57))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RLIFEDKATP CVPNARRIKK KKSKPPEKKS SRNYFGAQPH YRLCLGDMPF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CEP57 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CEP57 (Centrosomal Protein 57kDa (CEP57))
- Synonyms
- 3110002L15RIK Peptide, CEP57 Peptide, cep57r Peptide, xCep57 Peptide, c6orf182 Peptide, 3110002l15rik Peptide, RGD1309884 Peptide, 3110002L15Rik Peptide, 4921510P06Rik Peptide, 4931428M20Rik Peptide, AI467480 Peptide, Tsp57 Peptide, mKIAA0092 Peptide, MVA2 Peptide, PIG8 Peptide, TSP57 Peptide, centrosomal protein 57 Peptide, centrosomal protein 57kDa-like 1 Peptide, CEP57 Peptide, cep57l1 Peptide, Cep57 Peptide
- Background
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This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: CEP57,KIAA0092, TSP57,
Protein Size: 500 - Gene ID
- 9702
- NCBI Accession
- NP_055494
- UniProt
- Q86XR8
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