Poly A Binding Protein Nuclear 1 (PABPN1) (C-Term) Peptide
PABPN1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PABPN1 products
- PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- NRPGISTTDR GFPRARYRAR TTNYNSSRSR FYSGFNSRPR GRVYRGRARA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PABPN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
- Synonyms
- OPMD Peptide, PAB2 Peptide, PABII Peptide, PABP-2 Peptide, PABP2 Peptide, Pabp3 Peptide, mPABII Peptide, ARABIDOPSIS POLY(A) BINDING 2 Peptide, ATPAB2 Peptide, F28A23.130 Peptide, F28A23_130 Peptide, POLY(A) BINDING PROTEIN 2 Peptide, POLY(A)-BINDING PROTEIN 2 Peptide, poly(A) binding protein 2 Peptide, opmd Peptide, pab2 Peptide, pabp2 Peptide, pabpii Peptide, pabpn1 Peptide, Pabpn1 Peptide, Poly(A)-binding protein 2 Peptide, fb19c03 Peptide, wu:fb17e03 Peptide, wu:fb18c06 Peptide, wu:fb19c03 Peptide, zgc:85979 Peptide, zgc:92452 Peptide, poly(A) binding protein nuclear 1 Peptide, poly(A) binding protein, nuclear 1 Peptide, poly(A) binding protein 2 Peptide, poly(A) binding protein, nuclear 1 S homeolog Peptide, poly(A) binding protein, nuclear 1 L homeolog Peptide, polyadenylate-binding protein 2 Peptide, poly(A) binding protein Pab2 Peptide, PABPN1 Peptide, Pabpn1 Peptide, PAB2 Peptide, pabpn1.S Peptide, pabpn1.L Peptide, LOC100728725 Peptide, pab2 Peptide, pabpn1 Peptide
- Background
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This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
Alias Symbols: OPMD, PAB2, PABII, PABP2, PABP-2
Protein Size: 333 - Gene ID
- 8106
- NCBI Accession
- NM_001199839, NP_004634
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