Cytokine Inducible SH2-Containing Protein (CISH) (Middle Region) Peptide
CISH
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CISH products
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RILAFPDVVS LVQHYVASCT ADTRSDSPDP APTPALPMPK EDAPSDPALP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- CISH Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
- Synonyms
- CISH Peptide, cis Peptide, cish.a Peptide, ptk9l Peptide, twf1l Peptide, wu:fk57g04 Peptide, zgc:154062 Peptide, zgc:91817 Peptide, g18 Peptide, socs Peptide, cis-1 Peptide, cish Peptide, BACTS2 Peptide, CIS Peptide, CIS-1 Peptide, G18 Peptide, SOCS Peptide, AI385595 Peptide, CIS1 Peptide, Cis Peptide, F17 Peptide, F23 Peptide, cytokine inducible SH2 containing protein Peptide, cytokine inducible SH2-containing protein Peptide, CISH Peptide, cish Peptide, Cish Peptide
- Background
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The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CIS, G18, SOCS, CIS-1, BACTS2
Protein Size: 275 - Gene ID
- 1154
- NCBI Accession
- NM_013324, NP_037456
- UniProt
- Q9NSE2
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