CD209 (CD209) (Middle Region) Peptide
CD209
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all DC-SIGN/CD209 (CD209) products
- DC-SIGN/CD209 (CD209) (CD209)
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SRSNRFTWMG LSDLNQEGTW QWVDGSPLLP SFKQYWNRGE PNNVGEEDCA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- CD209 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DC-SIGN/CD209 (CD209) (CD209)
- Synonyms
- CDSIGN Peptide, CLEC4L Peptide, DC-SIGN Peptide, DC-SIGN1 Peptide, cd209 Peptide, CLEC4M Peptide, si:ch211-224h1.3 Peptide, CD209 Peptide, CIRE Peptide, Dcsign Peptide, SIGN-R1 Peptide, SIGNR5 Peptide, Cd209 Peptide, CD209 molecule Peptide, CD209a antigen Peptide, CD209 antigen-like protein D Peptide, CD209c molecule Peptide, CD209 antigen Peptide, CD209 Peptide, cd209 Peptide, Cd209a Peptide, LOC100529184 Peptide, Cd209c Peptide, LOC100460708 Peptide, LOC105484282 Peptide
- Background
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This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332, often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Alias Symbols: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Protein Size: 312 - Gene ID
- 30835
- NCBI Accession
- NM_001144893, NP_001138365
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