Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D) (Middle Region) Peptide
SEMA4D
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SEMA4D/CD100 (SEMA4D) products
- SEMA4D/CD100 (SEMA4D) (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ISRNSSHSPL RTEYAIPWLN EPSFVFADVI RKSPDSPDGE DDRVYFFFTE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- SEMA4D Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SEMA4D/CD100 (SEMA4D) (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D))
- Synonyms
- C9orf164 Peptide, CD100 Peptide, M-sema-G Peptide, SEMAJ Peptide, coll-4 Peptide, Semacl2 Peptide, Semaj Peptide, Semcl2 Peptide, COLL-4 Peptide, semaphorin 4D Peptide, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Peptide, Sema4d Peptide, SEMA4D Peptide
- Background
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Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system, induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Alias Symbols: CD100, SEMAJ, coll-4, C9orf164, M-sema-G
Protein Size: 862 - Gene ID
- 10507
- NCBI Accession
- NM_001142287, NP_001135759
- UniProt
- Q92854
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