TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (Middle Region) Peptide
TAB2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TAB2 products
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNNSSK LRSSGPRTSS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TAB2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
- Synonyms
- CHTD2 Peptide, MAP3K7IP2 Peptide, 1110030N06Rik Peptide, A530078N03Rik Peptide, Map3k7ip2 Peptide, mKIAA0733 Peptide, map3k7ip2 Peptide, zgc:77446 Peptide, TGF-beta activated kinase 1/MAP3K7 binding protein 2 Peptide, TAB2 Peptide, Tab2 Peptide, tab2 Peptide
- Background
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The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.
Alias Symbols: TAB2,KIAA0733,MAP3K7IP2,
Protein Size: 536 - Gene ID
- 23118
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