HLA Class II DR beta 3 (HLA-DRB3) (N-Term) Peptide
HLA-DRB3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HLA-DRB3 products
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TLMVLSSRLA FAGDTRPRFL ELRKSECHFF NGTERVRYLD RYFHNQEEFL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HLA-DRB3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))
- Synonyms
- HLA-DR3B Peptide, BLA-DRB3 Peptide, Bota-DRB01 Peptide, Bota-DRB02 Peptide, Bota-DRB04 Peptide, Bota-DRB07 Peptide, Bota-DRB21 Peptide, Bota-DRB22 Peptide, LA-DRB Peptide, major histocompatibility complex, class II, DR beta 3 Peptide, major histocompatibility complex, class II, DRB3 Peptide, HLA-DRB3 Peptide, BOLA-DRB3 Peptide
- Background
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HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Alias Symbols: SS1, DRB1, DRw10, HLA-DRB, HLA-DR1B, HLA-DR3B
Protein Size: 266 - Gene ID
- 3125
- NCBI Accession
- NM_022555, NP_072049
- UniProt
- P79483
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