Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4) (Middle Region) Peptide
PABPC4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PABPC4 products
- PABPC4 (Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AQMRPNPRWQ QGGRPQGFQG MPSAIRQSGP RPTLRHLAPT GSECPDRLAM
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PABPC4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PABPC4 (Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))
- Synonyms
- cb12 Peptide, sb:cb12 Peptide, PABP Peptide, ePAB Peptide, ePABP Peptide, APP-1 Peptide, APP1 Peptide, PABP4 Peptide, iPABP Peptide, polyadenylate-binding protein 4 Peptide, poly(A) binding protein, cytoplasmic 4 Peptide, poly(A) binding protein, cytoplasmic 4 (inducible form) Peptide, poly(A) binding protein cytoplasmic 4 L homeolog Peptide, poly(A) binding protein cytoplasmic 4 Peptide, Bm1_06880 Peptide, Pabpc4 Peptide, pabpc4 Peptide, pabpc4.L Peptide, PABPC4 Peptide
- Background
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Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: APP1, APP-1, PABP4, iPABP
Protein Size: 660 - Gene ID
- 8761
- NCBI Accession
- NM_001135653, NP_001129125
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