Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA) (Middle Region) Peptide
PIGA
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PIGA products
- PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- IICVSYTSKE NTVLRAALNP EIVSVIPNAV DPTDFTPDPF RRHDSITIVV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PIGA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))
- Synonyms
- GPI3 Peptide, MCAHS2 Peptide, PIG-A Peptide, AI194334 Peptide, Pig-a Peptide, im:6911675 Peptide, zgc:56589 Peptide, phosphatidylinositol glycan anchor biosynthesis class A Peptide, phosphatidylinositol glycan anchor biosynthesis, class A Peptide, PIGA Peptide, Piga Peptide, piga Peptide
- Background
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This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.
Alias Symbols: GPI3, PNH1, PIG-A, MCAHS2
Protein Size: 484 - Gene ID
- 5277
- NCBI Accession
- NM_002641, NP_002632
- UniProt
- P37287
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