Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A) (Middle Region) Peptide
KIR2DL5A
Reactivity: Human
Host: Synthetic
WB
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- Target See all KIR2DL5A products
- KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- MDQEPAGDRT VNREDSDDQD PQEVTYAQLD HCVFTQTKIT SPSQRPKTPP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))
- Synonyms
- CD158F Peptide, KIR2DL5 Peptide, KIR2DL5.1 Peptide, KIR2DL5.3 Peptide, KIR2DL5B Peptide, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Peptide, KIR2DL5A Peptide
- Background
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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: CD158F, KIR2DL5, KIR2DL5.1, KIR2DL5.3
Protein Size: 375 - Gene ID
- 57292
- NCBI Accession
- NM_020535, NP_065396
- UniProt
- Q8N109
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