Linker For Activation of T Cells (LAT) (Middle Region) Peptide
LAT
Reactivity: Human
Host: Synthetic
WB
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- Target See all LAT products
- LAT (Linker For Activation of T Cells (LAT))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- LPIPRSPQPL GGSHRTPSSR RDSDGANSVA SYENEGASGI RGAQAGWGVW
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- LAT (Linker For Activation of T Cells (LAT))
- Synonyms
- LAT Peptide, lat Peptide, LAT1 Peptide, pp36 Peptide, linker for activation of T-cells Peptide, linker for activation of T cells Peptide, LAT Peptide, lat Peptide, Lat Peptide
- Background
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The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: LAT1, pp36
Protein Size: 262 - Gene ID
- 27040
- NCBI Accession
- NM_001014987, NP_001014987
- UniProt
- O43561
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