Janus Kinase 1 (JAK1) (N-Term) Peptide
JAK1
Reactivity: Human
Host: Synthetic
WB
-
- Target See all JAK1 products
- JAK1 (Janus Kinase 1 (JAK1))
- Protein Region
- N-Term
- Origin
- Human
-
Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- RMRFYFTNWH GTNDNEQSVW RHSPKKQKNG YEKKKIPDAT PLLDASSLEY
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- JAK1 (Janus Kinase 1 (JAK1))
- Synonyms
- JAK1A Peptide, JAK1B Peptide, JTK3 Peptide, AA960307 Peptide, C130039L05Rik Peptide, wu:fb93e10 Peptide, jak1 Peptide, Janus kinase 1 Peptide, tyrosine-protein kinase JAK1 Peptide, JAK1 Peptide, Jak1 Peptide, jak1 Peptide, LOC100286690 Peptide
- Background
-
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
Alias Symbols: JTK3, JAK1A, JAK1B
Protein Size: 1154 - Gene ID
- 3716
- NCBI Accession
- NM_002227, NP_002218
- UniProt
- P23458
-
You are here:
