Protein Kinase N2 (PKN2) (Middle Region) Peptide
PKN2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PKN2 products
- PKN2 (Protein Kinase N2 (PKN2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SFMSRTSKSK SGSSRNLLKT DDLSNDVCAV LKLDNTVVGQ TSWKPISNQS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- PKN2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PKN2 (Protein Kinase N2 (PKN2))
- Synonyms
- PAK2 Peptide, PRK2 Peptide, PRKCL2 Peptide, PRO2042 Peptide, Pak-2 Peptide, 6030436C20Rik Peptide, AI507382 Peptide, Prkcl2 Peptide, Stk7 Peptide, pak2 Peptide, prk2 Peptide, pak-2 Peptide, pro2042 Peptide, PKN2 Peptide, si:ch211-83f14.1 Peptide, wu:fa97c07 Peptide, protein kinase N2 Peptide, protein kinase N2 L homeolog Peptide, PKN2 Peptide, Pkn2 Peptide, pkn2.L Peptide, pkn2 Peptide
- Background
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PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
Alias Symbols: PAK2, PRK2, STK7, Pak-2, PRKCL2, PRO2042
Protein Size: 827 - Gene ID
- 5586
- NCBI Accession
- NM_006256, NP_006247
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