Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (Middle Region) Peptide
PMAIP1
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all NOXA (PMAIP1) products
- NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
- Protein Region
- Middle Region
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TWSAPDITVV LAQMPGKSQK SRMRSPSPTR VPADLKDECA QLRRIGDKVN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- PMAIP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
- Synonyms
- TN3 Peptide, PMAIP1 Peptide, zgc:162379 Peptide, APR Peptide, NOXA Peptide, Noxa Peptide, phorbol-12-myristate-13-acetate-induced protein 1 Peptide, PMAIP1 Peptide, pmaip1 Peptide, Pmaip1 Peptide
- Background
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Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1.
Alias Symbols: Noxa
Protein Size: 103 - Gene ID
- 58801
- NCBI Accession
- NM_021451, NP_067426
- UniProt
- Q9JM54
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