Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) (Middle Region) Peptide
ITCH
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ITCH products
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KPSRPPRPSR PPPPTPRRPA SVNGSPSATS ESDGSSTGSL PPTNTNTNTS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- ITCH Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- Synonyms
- AIF4 Peptide, AIP4 Peptide, NAPP1 Peptide, dJ468O1.1 Peptide, 6720481N21Rik Peptide, 8030492O04Rik Peptide, A130065M08 Peptide, C230047C07Rik Peptide, itchy E3 ubiquitin protein ligase Peptide, itchy, E3 ubiquitin protein ligase Peptide, ITCH Peptide, Itch Peptide
- Background
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This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: AIF4, AIP4, ADMFD, NAPP1
Protein Size: 752 - Gene ID
- 83737
- NCBI Accession
- NM_001257137, NP_001244066
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