Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) (Middle Region) Peptide
NR1H3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NR1H3 products
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LEAAEPTALL TRAEPPSEPT EIRPQKRKKG PAPKMLGNEL CSVCGDKASG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- NR1H3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Synonyms
- NR1H3 Peptide, LXR-a Peptide, LXRA Peptide, RLD-1 Peptide, AU018371 Peptide, LXR Peptide, RLD1 Peptide, Unr1 Peptide, LXRalpha Peptide, LXR-alpha Peptide, im:7141239 Peptide, wu:fd59b01 Peptide, zgc:113339 Peptide, zgc:158542 Peptide, nuclear receptor subfamily 1 group H member 3 Peptide, nuclear receptor subfamily 1, group H, member 3 Peptide, NR1H3 Peptide, nr1h3 Peptide, Nr1h3 Peptide
- Background
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The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: LXRA, LXR-a, RLD-1
Protein Size: 402 - Gene ID
- 10062
- NCBI Accession
- NM_001130101, NP_001123573
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