Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) (C-Term) Peptide
NR1H3
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all NR1H3 products
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Protein Region
- C-Term
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LLIAISIFSA DRPNVQDQLQ VERLQHTYVE ALHAYVSINH PHDPLMFPRM
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Nr1h3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Synonyms
- NR1H3 Peptide, LXR-a Peptide, LXRA Peptide, RLD-1 Peptide, AU018371 Peptide, LXR Peptide, RLD1 Peptide, Unr1 Peptide, LXRalpha Peptide, LXR-alpha Peptide, im:7141239 Peptide, wu:fd59b01 Peptide, zgc:113339 Peptide, zgc:158542 Peptide, nuclear receptor subfamily 1 group H member 3 Peptide, nuclear receptor subfamily 1, group H, member 3 Peptide, NR1H3 Peptide, nr1h3 Peptide, Nr1h3 Peptide
- Background
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Nr1h3 is an orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Nr1h3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
Alias Symbols: AU018371, LXR, RLD1, Unr1
Protein Interaction Partner: Ppargc1a,Ppargc1b,Ppargc1a,Ppargc1b,Rxra,Rxrg,Ubc,Zfp111
Protein Size: 445 - Molecular Weight
- 50 kDa
- Gene ID
- 22259
- NCBI Accession
- NM_013839, NP_038867
- UniProt
- Q9Z0Y9
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