Topoisomerase (DNA) II alpha 170kDa (TOP2A) (C-Term) Peptide
TOP2A
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Topoisomerase II alpha (TOP2A) products
- Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PKGTKRDPAL NSGVSQKPDP AKTKNRRKRK PSTSDDSDSN FEKIVSKAVT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- TOP2A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
- Synonyms
- TOP2 Peptide, TP2A Peptide, TOP2A Peptide, Top-2 Peptide, TOP-2 Peptide, F12B17.110 Peptide, F12B17_110 Peptide, thimet metalloendopeptidase 2 Peptide, fc08c07 Peptide, wu:fc08c07 Peptide, DNA topoisomerase II alpha Peptide, DNA topoisomerase II, alpha isozyme Peptide, topoisomerase (DNA) II alpha Peptide, Zincin-like metalloproteases family protein Peptide, TOP2A Peptide, Bm1_08705 Peptide, Top2a Peptide, AT5G10540 Peptide, top2a Peptide
- Background
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This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Alias Symbols: TOP2, TP2A
Protein Size: 1531 - Gene ID
- 7153
- NCBI Accession
- NM_001067, NP_001058
- UniProt
- P11388
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