Ubiquitin Specific Peptidase 2 (USP2) (Middle Region) Peptide
USP2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all USP2 products
- USP2 (Ubiquitin Specific Peptidase 2 (USP2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GLHNEVNRVT LRPKSNPENL DHLPDDEKGR QMWRKYLERE DSRIGDLFVG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- USP2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- USP2 (Ubiquitin Specific Peptidase 2 (USP2))
- Synonyms
- UBP41 Peptide, USP9 Peptide, B930035K21Rik Peptide, Ubp41 Peptide, UBP-t Peptide, UBP46 Peptide, ubp52 Peptide, ubp66 Peptide, zgc:92134 Peptide, ubiquitin specific peptidase 2 Peptide, ubiquitin specific peptidase 2a Peptide, USP2 Peptide, Usp2 Peptide, usp2a Peptide
- Background
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This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: USP9, UBP41
Protein Size: 396 - Gene ID
- 9099
- NCBI Accession
- NM_001243759, NP_001230688
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