phospholipase C, gamma 1 (PLCG1) (N-Term) Peptide
PLCG1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Phospholipase C gamma 1 (PLCG1) products
- Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DKIEGAIDIR EIKEIRPGKT SRDFDRYQED PAFRPDQSHC FVILYGMEFR
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- PLCG1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))
- Synonyms
- NCKAP3 Peptide, PLC-II Peptide, PLC1 Peptide, PLC148 Peptide, PLCgamma1 Peptide, plc1 Peptide, nckap3 Peptide, plc-ii Peptide, plc148 Peptide, plcgamma1 Peptide, PPLCA Peptide, AI894140 Peptide, Cded Peptide, Plc-1 Peptide, Plc-gamma1 Peptide, Plcg-1 Peptide, fj46f04 Peptide, wu:fj46f04 Peptide, wu:fj57a05 Peptide, phospholipase C gamma 1 Peptide, phospholipase C gamma 1 L homeolog Peptide, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Peptide, phospholipase C, gamma 1 Peptide, PLCG1 Peptide, plcg1.L Peptide, LOC100633163 Peptide, Plcg1 Peptide, plcg1 Peptide
- Background
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The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1
Protein Size: 1290 - Gene ID
- 5335
- NCBI Accession
- NM_002660, NP_002651
- UniProt
- P19174
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