beta-Site APP-Cleaving Enzyme 2 (BACE2) (N-Term) Peptide
Quick Overview for beta-Site APP-Cleaving Enzyme 2 (BACE2) (N-Term) Peptide (ABIN8095538)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- BACE2 Peptide - N-terminal region
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Sequence
- PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-BACE2 Antibody(ARP46853_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
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Background
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Background Information: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Alternative Symbols: AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
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Molecular Weight
- 37kDa
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Gene ID
- 25825
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NCBI Accession
- NP_620477
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UniProt
- Q9Y5Z0
Target
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