Promyelocytic Leukemia (PML) Peptide
PML
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all PML products
- PML (Promyelocytic Leukemia (PML))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- EGPSTLRVLD ENLADPQAED RPLVFFDLKI DNETQKISQL AAVNRESKFR
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of PML antibody,
Alternative Names: PML control peptide, PML antibody Blocking Peptide, Anti-PML Blocking Peptide, promyelocytic leukemia Blocking Peptide, MYL Blocking Peptide, PP8675 Blocking Peptide, RNF71 Blocking Peptide, TRIM19 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- PML (Promyelocytic Leukemia (PML))
- Synonyms
- MYL Peptide, PP8675 Peptide, RNF71 Peptide, TRIM19 Peptide, 1200009E24Rik Peptide, AI661194 Peptide, Trim19 Peptide, RGD1562602 Peptide, PML Peptide, promyelocytic leukemia Peptide, PML Peptide, Pml Peptide
- Background
- PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus.
- Molecular Weight
- 59 kDa
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